196. SYNTHETIC HOLLOW ENZYME LOADED POROUS NANOSHELLS (SHELS) FOR ENZYME BASED THERAPIES

Department: NanoEngineering
Faculty Advisor(s): Sadik Esener

Primary Student
Name: Inanc Ortac
Email: iortac@ucsd.edu
Phone: 858-344-8108
Grad Year: 2012

Abstract
A novel therapeutic approach for enzyme based therapies that we refer to as SHELS can shield immunogenic enzymes by internally encapsulating them from immune system and other forms of degradation while maintaining the enzymes active close to ideal levels. SHELS have nanopores on the surface that allow enzyme substrates to easily diffuse in and products to diffuse out but prevent the larger enzymes to leak out preventing antibodies and other enzymes like proteases to penetrate and destroy the protected enzymes. SHELS surface can also be functionalized for targeting and improving circulation half-life eliminating any modification on the enzyme. Since SHELS are nanoshells, very small amount of inorganic mass is involved maximizing in vivo loading capacity. SHELS platform enables a variety of therapeutic approaches such as direct enzymatic depletion of tumor cell nutrients, enzymatic conversion of pro-drug to drug, and enzyme replacement therapy in addition to in vivo bio-sensing applications.

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