30. CONTROL OF THE BIOPHYSICAL PROPERTIES OF OSTEOARTHRITIC SYNOVIAL FLUID

Department: Bioengineering
Faculty Advisor(s): Robert Sah

Primary Student
Name: William J McCarty
Email: wmccarty@ucsd.edu
Phone: 858-534-5682
Grad Year: 2012

Abstract
BACKGROUND: Synovial fluid (SF) allows for low-friction and low-wear articulation of synovial joints, including the knee, hip, and shoulder. SF is an ultrafiltrate of plasma, with additional lubricants secreted by local cell populations. The most important and abundant lubricant is hyaluronan (HA), normally present in high molecular weight (MW) form, which gives SF its characteristic viscosity. During rheumatoid arthritis, osteoarthritis (OA), and after joint injury, SF loses its lubricating ability due to a loss of HA concentration and a shift to lower MW species. The aim of this work was to alter the biophysical properties of osteoarthritic SF, as a therapeutic intervention.

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