194. LIGHT-RESPONSIVE COMPOSITE BIOMATERIALS TO AID IN TRIGGERED DRUG DELIVERY

Department: NanoEngineering
Faculty Advisor(s): Shaochen Chen

Primary Student
Name: Kolin C Hribar
Email: khribar@ucsd.edu
Phone: 858-534-5602
Grad Year: 2016

Abstract
Stimuli-responsive materials, labeled smart materials, are a specific class of materials that respond to an external stimulus to produce a reversible material or structural change. Gold nanoparticles incorporated within a polymeric scaffold provide a novel way to drive temperature changes in the scaffold. Distinguishable from its bulk counterpart, gold at the nanoscale can absorb preferentially at certain wavelengths of light, attributed to its surface plasmon resonance. This absorption, in turn, is converted to heat, thus creating a robust light-to-heat (photothermal) platform. We utilize the photothermal effect to induce rapid thermal expansion of our of scaffolds in response to a femtosecond laser. After demonstrating that the heating is both reversible and repeatable, we apply this platform to drug delivery. We encapsulate FITC-dextran, a fluorescent molecule, within the scaffold and observe drug release in the lased areas and no drug release in the non-lased areas. These results suggest the drug has been released in response to the light, offering a novel method to trigger drug release.

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