92. SIMULATED RAMAN CORRELATION SPECTROSCOPY FOR NUCLEIC ACID-SILVER COMPOSITES BINDING ANALYSIS

Department: Electrical & Computer Engineering
Research Institute Affiliation: Graduate Program in Chemical Engineering
Faculty Advisor(s): Y. Shaya Fainman

Primary Student
Name: Lindsay Michelle Freeman
Email: lmfreema@ucsd.edu
Phone: 864-200-8013
Grad Year: 2016

Student Collaborators
Alexei Smolyaninov, a.smoly@gmail.com | Lin Pang, lin.lpang@gmail.com

Abstract
Plasmonic devices are of great interest due to their ability to confine light to the nanoscale level and dramatically increase the intensity of the electromagnetic field, functioning as high performance platforms for Raman signal enhancement. While Raman spectroscopy has been proposed as a tool to identify the preferential binding sites and adsorption configurations of molecules to nanoparticles, the results have been limited by the assumption that a single binding site is responsible for molecular adsorption. Here, we develop the simulated Raman correlation spectroscopy (SRCS) process to determine which binding sites of a molecule preferentially bind to a plasmonic material and in what capacity. We apply the method to the case of nucleic acids binding to silver, discovering that multiple atoms are responsible for adsorption kinetics. This method can be applied to future systems, such as to study the molecular orientation of adsorbates to films or protein conformation upon adsorption.

Industry Application Area(s)
Electronics/Photonics | Materials | Biosensing

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