95. WHOLE-CELL ELECTROCHEMICAL BIOSENSORS FOR LOW-COST POINT-OF-CARE APPLICATIONS

Department: Electrical & Computer Engineering
Faculty Advisor(s): Drew A. Hall

Primary Student
Name: Alexander Chuan Sun
Email: acs009@ucsd.edu
Phone: 650-393-3939
Grad Year: 2018

Student Collaborators
A.G. Venkatesh, agvenkatesh@eng.ucsd.edu

Abstract
Clinical diagnosis is a critical stage in effective treatment and disease surveillance, often associated with detailed methodologies and infrastructure requirements, and it is an economic burden for developing- and under developed-countries with limited resources. A point-of-care (POC) diagnostic devices with highly sensitive, yet affordable provide the functionality of an advanced laboratory in all settings. A whole cell-based electrochemical biosensors offer a promising and economical POC diagnostic solution. A Genetically engineered yeast cell expressing orientated affinity molecule called ?BioBricks? at the surface provide an avenue to reduce production cost, complexity in reagent production and purification, assay assembly, controlled storage condition requirements, and limited shelf life. Based on yeast aga1 ? aga2 system, the BioBricks contains specific affinity molecules targeted towards a biomarker and a gold binding peptide (GBP) which aids adhesion on to gold surface of an electrochemical working electrode. Integration of smartphone-based electrochemistry and whole cell-based assay enhances the application and reach of this new low-cost POC device concept.

Industry Application Area(s)
Electronics/Photonics | Life Sciences/Medical Devices & Instruments

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