179. TRACKING AND AIDING THE SURVIVAL OF STEM CELLS BY INDOCYANINE GREEN- AND INSULIN GROWTH FACTOR-LOADED MESOPOROUS CELLULAR FOAM

Department: NanoEngineering
Research Institute Affiliation: Graduate Program in Materials Science and Engineering
Faculty Advisor(s): Jesse V. Jokerst

Primary Student
Name: Fang Chen
Email: fachen@ucsd.edu
Phone: 858-534-6765
Grad Year: 2018

Student Collaborators
Junxin Wang, juw089@eng.ucsd.edu | Fang Wang, f4wang@eng.ucsd.edu

Abstract
It is crucial to increase stem cell survival and engraftment efficiency for regenerative medicine. Our previous work showed that mesoporous silica nanoparticle was an ultrasound-visible vehicle for insulin-like growth factor (IGF). Here, we report theranostic mesoporous cellular foam (MCF) silica nanoparticles to that can load both indocyanine green (ICG) and IGF. The ICG loaded MCF can not only produce ultrasound signal but also photoacoustic signals for real time cell tracking, so that we can improve the engraftment efficiency of stem cells. I studied the loading behavior of MCF for ICG and IGF. Loading capacity of MCF for ICG reached 169 ug ICG/mg MCF, and that of MCF for IGF 8.4 ug IGF/mg MCF. In vitro release of IGF showed that 0nly 7.2% IGF was released within one hour and 27% was released after one week.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials

Related Links:

  1. http://jjokerst.eng.ucsd.edu/
  2. https://docs.google.com/a/eng.ucsd.edu/viewer?a=v&pid=sites&srcid=ZW5nLnVjc2QuZWR1fGpva2Vyc3QtbGFifG
  3. https://docs.google.com/a/eng.ucsd.edu/viewer?a=v&pid=sites&srcid=ZW5nLnVjc2QuZWR1fGpva2Vyc3QtbGFifG

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