173. ACCELERATED DEGRADATION OF HYDROGEN PEROXIDE SENSITIVE POLYMERIC NANOPARTICLES VIA CHEMICAL AMPLIFICATION

Department: NanoEngineering
Faculty Advisor(s): Adah Almutairi

Primary Student
Name: Sangeun Lee
Email: sal093@ucsd.edu
Phone: 858-822-2942
Grad Year: 2018

Abstract
Reactive oxygen species (ROS) is getting more attention as a trigger for controlled drug release, being revealed it?s over expression in neurodegenerative disease, chronic obstructive pulmonary disease (COPD), arthritis, cancer, and inflammation,. However, most of the ROS sensitive systems require higher concentration than biological level of ROS and days for release of encapsulates. Thus it is still a challenge to develop a system having higher sensitivity to bio-relevant level of ROS and more effective release control. In here, pinacol boronic ester based hydrogen peroxide sensitively degradable polymer is proposed and demonstrated as a stimuli sensitive polymeric drug carrier. Reported polymer shows not only fast and complete degradation, but also burst release of encapsulates based on their signal amplifying degradation mechanism with bio-relevant concentration of H2O2

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