108. ACCELERATED WOUND HEALING THROUGH ELECTRICAL STIMULATION

Department: Electrical & Computer Engineering
Faculty Advisor(s): Tse Nga Ng | Yu-Hwa Lo

Primary Student
Name: Praful Jain
Email: p1jain@ucsd.edu
Phone: 408-981-6015
Grad Year: 2017

Student Collaborators
Udit Parekh, udparekh@eng.ucsd.edu

Abstract
Electrical stimulation therapy originates from the observation that wounded epithelial tissues generate a significant lateral electric field that is actively regulated by intact cells to transport ions and direct cell migration towards the wound. Manipulating the electrical properties at wound edges can reduce infection and oedema, increase perfusion, and improve cellular immunity and cell reproduction to speed up healing. Even though electrical stimulation (ES) has been shown to accelerate wound healing, the high cost of electrodes, limited clinical trials on humans and the lack of agreement on optimal ES stimulation parameters are the major barriers that have prevented practical implementation of ES for wound healing. Our proposed device addresses some of these barriers since our electrodes are fabricated by low-cost additive printing, and multiple electrodes are integrated into one flexible, stretchable structure for easy application. Similar to a conventional wound dressing, the electrodes are compatible with continuous wear for several days, to minimize undesirable disturbances that may re-open wounds and regress healing. The development of the proposed device also allows a consistent approach to ES application and quantitative evaluation in order to identify the optimal ES parameters for accelerating healing. The same flexible electrode array developed for ES therapy is used for impedance measurement to infer the tissue barrier integrity and healing rate. This helps us in quantitatively tracking wound healing progress post-ES, hence providing local control and feedback on the electric stimulation of cutaneous wounds.

Industry Application Area(s)
Electronics/Photonics | Life Sciences/Medical Devices & Instruments | Materials

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