38. MECHANICAL PROPERTIES OF PORCINE CORTICAL BONE AND BIOINSPIRED BONE: VERIFICATION OF THE INTERPENETRATING COMPOSITE STRUCTURE OF BONE

Department: Mechanical & Aerospace Engineering
Research Institute Affiliation: Agile - CaliBaja Center for Resilient Materials & Systems
Faculty Advisor(s): Joanna M. McKittrick

Primary Student
Name: Frances Yenan Su
Email: fysu@ucsd.edu
Phone: 858-534-5425
Grad Year: 2018

Abstract
Bone is composed of biopolymers (collagen and non-collagenous proteins) and biogenic hydroxyapatite. However, there is debate as to the structure of bone on the nanostructural level. While the bone has been previously thought to be composed of mineral particles suspended in a biopolymer matrix, it is hypothesized here that the biopolymers and mineral in bone actually form an interpenetrating composite. Mechanical properties, such as ultimate compressive strength and elastic modulus of demineralized, deproteinized, and untreated porcine femoral bone at different levels of maturity were compared. Bioinspired composite materials based on the interpenetrating composite model were created. First, a micro-computed tomography was used to obtain a 3-D reconstruction of the bone. Then, the bone model was 3-D printed and tested for its mechanical properties and compared to the model with suspended mineral particles, which was created using computer-aided design software and 3-D printing. This research is supported by the National Science Foundation (DMR-1507978).

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials | Bioinspired Materials

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