58. APPLICATION OF 3D ORGAN-ON-CHIP TECHNOLOGY TOWARDS CREATING IN VITRO CANCER MODELS

Department: Bioengineering
Faculty Advisor(s): Shyni Varghese

Primary Student
Name: Aereas Aung
Email: aeaung@ucsd.edu
Phone: 858-822-7920
Grad Year: 2016

Student Collaborators
Jomkuan Theprungsirikul, lynn.thep@gmail.com

Abstract
In 2015, cancer was the second leading cause of death in the United States where one in four deaths were cancer-related. Despite such grim outlooks, the survival rate amongst cancer patients has steadily increased from 49% to 68% over the past decade due to the increased understanding of this disease and therapeutic advances. To facilitate this process, we have developed an in vitro cancer model to screen novel oncologic drugs and study cancer-stromal interactions. Specifically, we encapsulated cancer spheroids along with endothelial cells in a gelatin hydrogel structure within a microfluidics device. Harnessing the differential motility of entrapped cells, we used a chemotactic gradient to induce the migration of endothelial cells to the periphery to form a vascular barrier. Using an established model cancer drug Doxorubicin, we demonstrated the drug screening potential for this device. Furthermore, we have incorporated macrophages within the hydrogel structure to create a tri-culture system to better recapitulate the tumor-immune interactions present within in vivo tumors.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

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