89. INTEGRATED SURFACE PLASMON RESONANCE AND FARADAIC ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY DEVICE FOR BIOSENSING
Name: Brandon John Sung Hyun Hong
Grad Year: 2018
An integrated biosensor based on surface plasmon resonance (SPR) and Faradaic electrochemical impedance spectroscopy (f-EIS) sensing modalities was developed for the simultaneous detection of biochemical analytes. To collocate the measurement areas, thin-film gold SPR-transducer gratings are holographically patterned into coplanar electrodes for in-tandem impedance sensing. Angular spectroscopy of surface plasmon resonance and the extraction of charge transfer resistance values from reduction-oxidation reactions at the gold surface are used to measure functionalized surface binding events. Using our scalable and compact detection system, non-interference between plasmonic and electrochemical measurement processes is shown, and biotinylated surface capture of neutravidin concentrations as low as 10 nM detection are demonstrated, with a 5.5 nM limit of detection.