193. PLATELET MEMBRANE-COATED NANOPARTICLES FOR BIOINTERFACING

Department: NanoEngineering
Faculty Advisor(s): Liangfang Zhang

Primary Student
Name: Ashley Victoria Kroll
Email: akroll@ucsd.edu
Phone: 858-246-0999
Grad Year: 2020

Student Collaborators
Diana Dehaini, ddehaini@ucsd.edu

Abstract
Despite the advances in nanoengineering and surface chemistry, bottom-up surface functionalization approaches remain inadequate in mimicking complex surfaces found in nature and cannot avoid the use of foreign, possibly immunogenic materials. Here we report on the preparation of polymeric nanoparticles coated in the plasma membrane of human platelets, which are a unique population of cellular fragments that adhere to a variety of disease-relevant substrates. The resulting nanoparticles possess a right-side-out platelet membrane coating that retains the surface properties of natural platelets. Compared to uncoated particles, the platelet membrane-cloaked nanoparticles (PNPs) have reduced cellular uptake by macrophage-like cells and lack particle-induced immune system activation cascades. The cloaked nanoparticles also display platelet-mimicking properties such as selective adhesion to damaged human and rodent vasculatures as well as enhanced binding to platelet-adhering pathogens. In an experimental rat model of coronary restenosis and a mouse model of systemic bacterial infection, docetaxel and vancomycin, respectively, show enhanced therapeutic efficacy when delivered by the PNPs. The multifaceted biointerfacing enabled by the platelet membrane cloaking method provides a new approach in developing functional nanoparticles for disease-targeted delivery.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials

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