14. WEARABLE SALIVARY METABOLITE MOUTHGUARD BIOSENSOR WITH INTEGRATED WIRELESS ELECTRONICS

Department: Electrical & Computer Engineering
Research Institute Affiliation: Agile Center for Wearable Sensors (CWS)
Faculty Advisor(s): Patrick P. Mercier | Joseph Wang

Primary Student
Name: Somayeh Imani
Email: soimani@ucsd.edu
Phone: 505-620-7084
Grad Year: 2018

Student Collaborators
Jayoung Kim, jak082@ucsd.edu

Abstract
In this work, we demonstrate an instrumented mouthguard capable of non-invasively monitoring salivary uric acid (SUA) levels. The enzyme (uricase)-modified screen printed electrode system has been integrated onto a mouthguard platform along with anatomically-miniaturized instrumentation electronics featuring a potentiostat, microcontroller, and a Bluetooth Low Energy (BLE) transceiver. Unlike RFID-based biosensing systems, which require large proximal power sources, the developed platform enables real-time wireless transmission of the sensed information to standard smartphones, laptops, and other consumer electronics for on-demand processing, diagnostics, or storage. The mouthguard biosensor system offers high sensitivity, selectivity, and stability towards uric acid detection in human saliva, covering the concentration ranges for both healthy people and hyperuricemia patients. The new wireless mouthguard biosensor system is able to monitor SUA level in real-time and continuous fashion, and can be readily expanded to an array of sensors for different analytes to enable an attractive wearable monitoring system for diverse health and fitness applications.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

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