57. AGE-RELATED IN VIVO BIOMATERIAL-MEDIATED BONE REGENERATION

Department: Bioengineering
Faculty Advisor(s): Shyni Varghese | Mengqian Liu

Primary Student
Name: Mengqian Liu
Email: mel093@ucsd.edu
Phone: 213-806-0151
Grad Year: 2018

Abstract
As a highly dynamic organ, bone continuously remodels and its regeneration abilities change throughout an individual's lifespan. These may be caused by declines in number or function of osteoprogenitor cells, and changes in the signaling microenvironment at defect sites, including the activities of immune and vascular cells. Understanding how these changes affect the efficacy of synthetic bone implant is crucial for the development of more effective therapeutic strategies to treat bone defects. In this study, we have examined age-related host responses to a biomineralized PEGDA-co-A6ACA graft using a mouse critical-sized cranial defect model. This bone graft is developed by using principles of biomineralization, which is inspired by the mineral-rich physicochemical cues of the native bone tissue. We evaluated endogenous cell recruitment, calcification, vascularization and inflammatory responses of mice with different age groups (1, 2, 6 and 14 month-old) to this implant after 2 and 8 weeks of implantation. Our findings show the biomineralized graft is able to completely heal the defect site for all ages in an age-dependent manner. These findings may provide new insight on bone defect treatment in the elderly.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials

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