59. BIOMINERALIZED MATERIAL-ASSISTED HEALING OF CRITICAL-SIZED BONE DEFECTS

Department: Bioengineering
Faculty Advisor(s): Shyni Varghese

Primary Student
Name: Eva Carolina Gonzalez Diaz
Email: ecgonzal@ucsd.edu
Phone: 858-822-7986
Grad Year: 2018

Abstract
Bone is one of the most commonly transplanted tissues, second only to blood. Currently, autografts and allografts are the primary choice of implants, but these suffer from various drawbacks such as donor site morbidity, scarcity, immunorejection, or risk of disease transmission.Thus, there exists a critical need for developing new approaches to promote bone repair. Novel biomaterials with intrinsic osteoconductivity, osteoinductivity, and osteogenicity have the potential to provide a safe and widely accessible method for treating critical bone defects. We have recently developed a biomineralized scaffold capable of modulating calcium phosphate concentrations to successfully recapitulate the dynamic bone mineral environment. Our previous studies have shown that these matrices are capable of inducing osteogenic differentiation of stem cells and promoting ectopic bone tissue formation in vivo in the absence of cells or growth factors such as BMP-2. Furthermore, our studies show that these biomineralized matrices can be used to direct healing of a critical-size cranial bone defect. By providing physicochemical cues, these biomineralized matrices induce osteogenic commitment of recruited host progenitor cells, resulting in the formation of dense, vascularized bone tissue and complete healing of the defect. Such a biomaterial-based strategy provides an effective and easy-to-implement alternative for bone tissue regenerative therapy.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials

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