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San Diego, CA, September 9, 2003 -- Marking a milestone in the evolution of the field of tissue engineering, bioengineers with the University of California, San Diego (UCSD) Jacobs School of Engineering have completed the first textbook on the subject. "Tissue Engineering" (Prentice Hall, 2004) was co-authored by Sangeeta Bhatia and Bernhard O. Palsson, and is now available at the Prentice Hall website.

"The book is solid, informative, and well-written," said Edwin N. Lightfoot, professor emeritus of chemical and biological engineering at University of Wisconsin-Madison. "Bhatia and Palsson have taken fundamental knowledge about several fields and shown how it fits together at higher levels of complexity."

"Up until now, there has not been a comprehensive resource available for teaching tissue engineering," said Y.C. Fung, UCSD professor emeritus of bioengineering. "Bhatia and Palsson have brought together their separate expertise of the components of tissue engineering into a very useful and powerful work that will have an important impact on this field."

Tissue engineering combines basic biological sciences, engineering fundamentals, medicine and biotechnology in the study of tissue dynamics that coordinate tissue repair, replacement, and reconstruction. In "Tissue Engineering" these diverse concepts are laid out in a clear framework organized around four themes: Quantitative Cell and Tissue Biology, including tissue organization, tissue dynamics, morphogenesis, stem cells, cellular fate processes and their coordination; Cell and Tissue Characterization, including high-throughput technologies, cell and tissue properties, cell and tissue culture, and gene transfer; Engineering Methods and Design, including time constant analysis, scale-up procedures, cell separations, biomaterial scaffolds and how to tailor biomaterials; and Clinical Implementation, including conventional approaches to tissue repair, host integration, and producing tissue-engineered therapies.

The book is targeted to instructors teaching senior-level and first-year graduate courses in tissue engineering; and to students researching tissue replacement and restorations as well as those working with primary and complex cell biology.

"We've tried to cover important fundamental concepts so that the book will serve as a practical guide in the field even as tissue engineering changes, and in order to help students establish a conceptual framework within which to place further advances in the field," said Palsson.

"The book is broad based so instructors can build comprehensive courses and have to flexibility to emphasize and expand on any particular topic. We've also provided homework sets to give students the opportunity to apply the concepts they are learning throughout the text."

The book was made possible through support from the Whitaker Foundation.


Bernhard Palsson is a Professor of Bioengineering and Adjunct Professor Medicine at the University of California, San Diego. He is the author of over 180 peer reviewed scientific articles and inventor of over 20 U.S. patents, many of which are in the area of hematopoietic stem cell transplantation, cell culture technology, bioreactor design, gene transfer, cell separations, in silico model building and metabolic engineering. Palsson is a co-founder of Aastrom Biosciences, Oncosis and Genomatica. He holds a Ph.D. (1984) from the University of Wisconsin.

Sangeeta N. Bhatia is an Associate Professor of Bioengineering at the University of California, San Diego. She has been recognized with the Packard Fellowship the NSF Career Award. Prof. Bhatia has industrial experience in medical devices, pharmaceutical and biotechnology, and holds patents for both clinical and biotechnology inventions. Her expertise is in the area of interfacing micro- and nanotechnology with mammalian cells with a particular emphasis on engineering liver tissue. Prof. Bhatia received her Ph.D. in Medical Engineering and Medical Physics at MIT and her M.D. at the Harvard Medical School.

Media Contact:
     Denine Hagen, (858) 534-2920,

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