165. development of an intraocular pressure measurement system

Department: Mechanical & Aerospace Engineering
Research Institute Affiliation: Center for Magnetic Recording Research (CMRR)
Faculty Advisor(s): Frank E. Talke

Primary Student
Name: Alex Minh Giang Phan
Email: mgphan@ucsd.edu
Phone: 310-701-0252
Grad Year: 2017

Student Collaborators
Phuong Truong, p1truong@ucsd.edu | Alexander Kief, alexanderkief@yahoo.de

Abstract
To date, elevated intraocular pressure (IOP) continues to be the primary risk factor for glaucoma due to its association with optic nerve damage and irreversible blindness. For approximately 60 million people worldwide suffering from this disease, careful monitoring and lowering of eye pressure are essential to mitigating further vision loss and optic nerve deterioration. Current standard care, which involves routine IOP measurements during office visits, can only provide snapshots of the patient's IOP profile. Such infrequent single-point measurements are inadequate to fully represent and characterize the patterns associated with glaucoma. As a result, there is a need for direct and continuous measurements of IOP to fully understand and accurately track the progression of the disease. The objective of this project is to develop a novel passive optical-based pressure sensor that allows monitoring of the IOP on a frequent or semi-continuous basis. In our studies, we have successfully designed, fabricated and optimized an intraocular pressure sensor capable of measuring small changes in pressure in both in-vitro (artificial cornea) and ex-vivo rabbit eye models. Mathematical models were developed to allow us to optimize the design parameters, material selection, and optical read-out. Using optimized parameters, a series of fabrication steps were implemented to fabricate and miniaturize the sensor. Our experimental results show a resolution of 0.8 mmHg in the clinically relevant physiological range and good correlation with mathematical models.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials

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