136. expanding cardiopulmonary shunt

Department: Mechanical & Aerospace Engineering
Faculty Advisor(s): James R. Friend

Primary Student
Name: Edward Aminov
Email: eaminov@ucsd.edu
Phone: 917-209-4840
Grad Year: 2017

Abstract
Congenital heart defects, or abnormal developments of the heart or major blood vessels, are the most common birth defects in the United States, annually affecting 35,000 infants. Annually, 1,300 infants undergo palliative surgery to maintain the required blood flow needs until a reparative surgery can be performed 6 months after birth. The current palliative surgery uses a pliable Gore-Tex tube as a shunt between an infant's systemic arteries and pulmonary artery to move blood to the lungs for re-oxygenation. Improper sizing of the shunt has consistently led to a 15%-25% mortality/morbidity rate since the shunts introduction in 1944. Additionally, the palliative surgery can cost as much as $1 million per infant. Our proposal is to create a bioabsorbable shunt cuff that releases the constriction of the shunt gradually over time to provide the infant with adequate blood flow as the infant doubles in size during the first 6 months of life. This research presents a novel technique for fabrication of complex geometry structures with Polycaprolactone which allows for varying layers of porosity within the structure. Polycaprolactone sheets of 125um, 250um, and 500um were fabricated and molded to create the complex elliptical geometry of the shunt cuff. The research further studies the effects of cyclic loading on the dissolution of bioabsorbable materials in vitro. Further, ANSYS dissolution modeling is applied to study the effect of pore size and porosity on dissolution of biomaterials. The fabrication technique and the dissolution properties of polycaprolactone can be engineered to create a bioabsorbable shunt cuff that satisfies the needed dissolution and strength properties required for our application.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

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