196. erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization

Department: NanoEngineering
Faculty Advisor(s): Liangfang Zhang

Primary Student
Name: Diana Dorothy Nader Dehaini
Email: ddehaini@ucsd.edu
Phone: 858-534-1308
Grad Year: 2019

Cell-membrane-coated nanoparticles are a new class of engineered materials which have excellent biocompatibility. These particles retain the properties of their membrane?s cell type, and can be adapted for variety of therapeutic and imaging applications. This class of nanoparticles includes those derived from red blood cells (RBCs), platelets, white blood cells, cancer cells, and bacteria, each which exhibit properties characteristic of the source cell. In this study, membrane material from two different cells is fused to create a hybrid membrane-coated particle, providing a facile method for further enhancing nanoparticle functionality. The resulting RBC?platelet hybrid membrane-coated nanoparticles are thoroughly characterized, and it is shown that they carry properties of both source cells. Further, the platform exhibits long circulation and suitability for further in vivo exploration. The reported strategy opens the door for the creation of biocompatible, custom-tailored biomimetic nanoparticles with varying hybrid functionalities, which may be used to overcome the limitations of current nanoparticle-based therapeutic and imaging platforms.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Nanomedicine, Drug delivery

Related Links:

  1. http://onlinelibrary.wiley.com/doi/10.1002/adma.201606209/full

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