197. red blood cell membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against mrsa infection

Department: NanoEngineering
Faculty Advisor(s): Liangfang Zhang
Award(s): Department Best Poster

Primary Student
Name: Yue Zhang
Email: yuz321@ucsd.edu
Phone: 858-246-0999
Grad Year: 2019

Abstract
We developed an red blood cell membrane(RBC) coated redox-responsive nanogel system for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. The RBC membrane coating was achieved via a membrane templated in-situ polymerization process, while the redox responsiveness was enabled by incorporating the disulfide bond based crosslinker into the nanogel network. The results indicated that the RBC membrane coating could effectively neutralize the pore forming toxin secreted by MRSA bacteria which in turn promoted bacterial phagocytosis by THP-1 derived macrophage. On the other hand, the loaded antibiotic in nanogels was released when uptaked into the lysosome. The concentrated intracellular antibiotic could eliminate the bacteria burden in the macrophage. Conclusively, the RBC-coated redox-responsive nanogel system serves as a new and promising antimicrobial agent against MRSA infection.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials

Related Links:

  1. http://www.sciencedirect.com/science/article/pii/S0168365917300196

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