6. eyeglasses wireless electrochemical sensor platform

Department: NanoEngineering
Research Institute Affiliation: Agile Center for Wearable Sensors (CWS)
Faculty Advisor(s): Joseph Wang

Primary Student
Name: Juliane R Sempionatto Moreto
Email: jsempion@ucsd.edu
Phone: 858-822-1588
Grad Year: 2020

Abstract
With the tremendous interest in wearable sensor platforms, we demonstrate the first example of a fully-integrated wireless eyeglasses-based multiplexed biosensor platform for simultaneous real-time monitoring of sweat electrolytes and metabolites. Eyeglasses represent an attractive wearable platform. Since Google launched its Google Glass project, developers from around the globe have focused on introducing smart glasses as wearable computers and display devices. However, despite of being an attractive wearable platform, there are no reports on eyeglasses based non-invasive chemical sensors. Eyeglasses are widely worn daily by millions, compared to other accessories, e.g., wrist bands, head bands and tattoos, commonly used for wearable sensor systems. The inherent shape and weight of glasses conform well to the user face and the pressure in the nose bridge pads promotes good sensor-skin contact. The new wearable glasses chemical sensing platform has been realized by integrating potentiometric and amperometric sensors on the nose-bridge pads of the glasses and integrating them to a homemade wireless electronic backbone located along the glasses arms. These nose-bridge electrochemical sensors were fabricated via conventional screen-printing technique utilizing custom-designed stencils. The sensor patterns and contacts were printed on a polyethylene terephthalate (PET) substrate, used as replaceable sticker on the nose pad via a double-sided adhesive tape. These easily removable adhesive sensor stickers allow the user to select the target metabolite and electrolyte he/she wishes to monitor. All connections were fixed within the nose bridge pad and the glasses. Therefore, the 'Lab-on-a-Glass' platform can thus be adjusted to meet the specific wearer?s needs. Considering the importance of potassium and lactate bio-markers, they were used to demonstrate the real time simultaneous monitoring capabilities of the eyeglasses during physical activity of three healthy subjects. Consistent results were obtained. The sensor stickers of the new eyeglasses sensing platform can be readily replaced and the system can thus be readily extended for the monitoring of a wide variety of target analytes. In order to demonstrate this feature, the lactate sensor sticker was replace by a glucose sensor and the sweat glucose was successful monitored during exercise. The eyeglasses based chemical sensing offers comfort and ease of use to the wearer while ensuring good sensor-skin contact. Such fully-integrated wireless ?Lab-on-a-Glass? multiplexed biosensor platform can be readily expanded for the simultaneous monitoring of additional sweat electrolytes and metabolites.

Industry Application Area(s)
Electronics/Photonics | Internet, Networking, Systems | Life Sciences/Medical Devices & Instruments

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