119. flexible porous graphene electrodes with low impedance and high charge injection capacity for cortical sensing and stimulation

Department: Electrical & Computer Engineering
Research Institute Affiliation: Graduate Program in Computational Science, Mathematics, and Engineering (CSME)
Faculty Advisor(s): Duygu Kuzum

Primary Student
Name: Yichen Lu
Email: yil051@ucsd.edu
Phone: 215-588-7604
Grad Year: 2020

Abstract
Neuroscience research and clinical brain-machine interfaces require safe and efficient neural sensing and stimulation. To-date, most of the neural stimulation systems have relied on sharp metal microelectrodes with poor electrochemical properties that induce extensive damage to the tissue and significantly degrade the long-term stability of implantable systems. Therefore, efficient and durable electrophysiological sensing and stimulation without penetrating brain tissue is of great research interest. Here, we demonstrate a flexible cortical microelectrode array based on porous graphene. This material shows low impedance and high charge injection, being ideal for high efficiency cortical sensing and stimulation. It also exhibits no physical delamination or degradation after 1 million biphasic stimulation cycles, confirming long-term endurance. Moreover, porous graphene is easy to fabricate with direct laser pyrolysis, providing a great potential for large area fabrication and commercialization. In in vivo experiments with rodents, same porous graphene array is used to sense brain activity patterns with high spatio-temporal resolution and to control leg muscles with high precision electrical stimulation from the cortical surface. Flexible porous graphene array offers a minimally invasive but high efficiency neuromodulation scheme with potential applications in cortical mapping, brain-computer interfaces, treatment of neurological disorders, where high resolution and simultaneous recording and stimulation of neural activity are crucial.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

Related Links:

  1. http://www.nature.com/articles/srep33526

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