118. a multi-modal system for closed-loop optogenetics in behaving animals

Department: Electrical & Computer Engineering
Faculty Advisor(s): Duygu Kuzum | Xin Liu

Primary Student
Name: Xin Liu
Email: xil432@ucsd.edu
Phone: 858-344-0623
Grad Year: 2021

Student Collaborators
Yichen Lu, yil051@eng.ucsd.edu | Ege Iseri, eiseri@eng.ucsd.edu | Sravya Alluri, sralluri@eng.ucsd.edu

In recent years, optogenetics is becoming increasingly popular in neural modulations and neural circuit investigations. The combination of electrophysiology and optogenetics provides high resolutions in both time and spatial domain. Conventionally, metal microelectrodes are used for electrical recording of neural activities. However, these non-transparent electrodes block the optical view and suffer from light-induced artifacts. These drawbacks make the metal electrodes difficult to be used with optogenetics. Here we proposed a portable closed-loop neural recording system for simultaneous electrophysiology and optogenetics control. The battery powered system consists of 16 transparent graphene electrodes, 4 μLEDs for optogenetics, and a low power consumption microcontroller. This system can be used in the study and control of specific neural populations in behaving animals.

Industry Application Area(s)
Control Systems | Electronics/Photonics | Life Sciences/Medical Devices & Instruments

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