54. cardiovascular response to resuscitation with anaerobically stored blood

Department: Bioengineering
Faculty Advisor(s): Pedro J. Cabrales Arevalo

Primary Student
Name: Alexander Thomas Williams
Email: atwillia@ucsd.edu
Phone: 858-534-8197
Grad Year: 2018

Hemorrhage severely decreases oxygen delivery due to decreased myocardial contractility and a sudden drop in hemoglobin (Hb). Physicians respond to hemorrhage by infusing large volumes of stored red blood cells (RBCs) to both restore blood volume as well as Hb concentration. Conventionally stored RBCs are susceptible to both biochemical and mechanical changes that decrease their ability to effectively deliver oxygen to tissues. However, when cells are stored in anaerobic conditions (Hb saturation <10%) or anaerobic and hypercapnic conditions (Hb sat <10%, CO2 5%), this biochemical and mechanical deterioration is reduced. Sprauge-Dawley rats were used to show that 24-hour recovery of anaerobically stored RBCs was significantly higher than conventionally stored RBCs. Additionally, Sprauge-Dawley rats were hemorrhaged and resuscitated with either 1-week-old or 3-week-old blood stored conventionally, anaerobically, or anaerobically with hypercapnia. Cardiac function was assessed during shock and resuscitation using a miniaturized pressure-volume catheter in the left ventricle. Studies indicate that anaerobic storage of blood could improve clinical outcomes.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

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