134. non-invasive quantitative method for measuring regional cardiac function.

Department: Mechanical & Aerospace Engineering
Faculty Advisor(s): Juan Carlos Del Alamo

Primary Student
Name: Ashish Manohar
Email: asmanoha@ucsd.edu
Phone: 858-534-5962
Grad Year: 2017

Abstract
Tracking and assessing the regional contractility of the heart has important implications in the diagnosis and treatment of cardiac diseases. In particular, assessing the regional function of the left ventricle (LV) is important as it is the chamber responsible for systemic circulation and its dysfunction can have a direct correlation to diseases such as myocardial ischemia and myocardial dyssynchrony. Angiography is the most prevalent procedure currently which is used to diagnose and assess blood supply in the coronary arteries. However, this requires the insertion of a catheter and the injection of a radio-opaque contrast agent into the blood vessel for X-ray imaging. We developed an analysis framework to quantify regional cardiac function non-invasively from high-resolution CT scans. The framework utilizes the highly complex and irregular structure of the LV endocardium and allows us to characterize this surface through its fractal dimension. We track changes in the local values of this fractal dimension across different time frames of the cardiac cycle and process this information to identify regions of abnormal contraction. The tool is simple, requires minimal operator involvement, and completes the entire analysis in a time frame of the order of ~10 minutes. This tool has the potential to be incorporated into a bed-side non-invasive diagnostic device which will give the physician information on the local contractile function of the heart, thereby saving time, money and minimizing patient discomfort.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

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