66. a novel mathematical model to simulate cardiac biomechanics

Department: Bioengineering
Faculty Advisor(s): Andrew D. Mc Culloch

Primary Student
Name: Jessica Caitlin Leon
Email: j4leon@ucsd.edu
Phone: 408-332-6594
Grad Year: 2017

Abstract
The cardiovascular system is regulated through numerous control systems, which operate on various time scales. The baroreflex acts in milliseconds to seconds, responding to acute changes in pressure by altering heart rate, heart contractility, and blood vessel diameter. Blood volume control acts on a time scale of minutes to hours, in which the kidneys regulate blood pressure by means of blood plasma osmolarity and volume in the circulatory system. When pressure is altered on a time scale of days to years, growth and remodeling occur in the heart wall. These different time scales are coupled in a mathematical model developed in MATLAB such that their summed or individual effects can be visualized. This results in a more physiological model of the circulatory system than previous models, and generates pressure-volume curves over time. There is great potential for multi-scale models such as this to be used by researchers and medical professionals in the study of pathophysiological conditions and in generating patient-specific models of cardiac biomechanics.

Industry Application Area(s)
Control Systems | Life Sciences/Medical Devices & Instruments | Software, Analytics

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