15. central blood pressure waveform monitoring by conformal ultrasonic devices

Department: NanoEngineering
Research Institute Affiliation: Center for Wearable Sensors
Faculty Advisor(s): Sheng Xu

Primary Student
Name: Chonghe Wang
Email: chw324@ucsd.edu
Phone: 858-405-8161
Grad Year: 2018

Abstract
Monitoring of central blood pressure (CBP) waveform from deeply embedded vessels, such as the carotid artery and jugular vein, has significant clinical values due to their proximity to the heart. The CBP waveform has a direct relationship with the cardiovascular status such as atrial and ventricular activities on both left and right sides. The most accurate method for measuring CBP, namely cannulation, is too invasive to allow frequent measurements that are needed for many conditions related to all-cause cardiovascular mortality prediction. Existing non-invasive solutions, including photoplethysmography and tonometry, have significant challenges to provide accurate and reliable measurements on blood vessels that are deep underneath the skin. Here, we demonstrate a skin-integrated conformal ultrasonic device that overcomes these limitations by combined strategies of material design and advanced microfabrication. The ultrasonic device has an ultrathin profile (240 μm in thickness), a high reversible stretchability (60%), and a comparable axial resolution (400 μm) with commercial transducers. This study demonstrates the first conformal electronics capable of launching ultrasonic waves that penetrate into deep tissues non-invasively, in a gel-free manner, and acquire accurate CBP waveforms at deeply embedded arterial and venous sites to monitor cardiovascular events. Also, this is the first conformal device that enables observing the prominent pressure amplification caused by progressive stiffness along the arterial tree, by comparing the captured peripheral blood pressure (PBP) with the CBP waveforms. Additionally, this device allows correlating the blood pressure waveforms at different locations of the body with a simultaneous electrocardiogram (ECG) to evaluate arterial stiffness along conduit arteries. Collectively, this opens up wide opportunities for continuous and accurate deep tissue diagnosis and prognosis using non-invasive wearable electronics.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

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