167. development of an artificial cornea for monitoring intraocular pressure in corneal transplant patients

Department: Mechanical & Aerospace Engineering
Faculty Advisor(s): Frank E. Talke

Primary Student
Name: Phuong Thi Ngoc Truong
Email: p1truong@ucsd.edu
Phone: 626-454-9574
Grad Year: 2020

Student Collaborators
Alex Phan , mgphan@gmail.com | Kerrianne Stewart , kerrianne95@gmail.com | Ella Stimson , eastimso@ucsd.edu | Buu Truong , buutruong1@gmail.com

Abstract
Glaucoma is considered the second leading cause of blindness worldwide with an estimated 112 million cases by 2040. To date, intraocular pressure (IOP) is considered as a primary risk factor for the progression of the disease and is typically measured in clinic using a Goldmann applanation tonometer. The current gold standard indirectly measures eye pressure by determining the force required to flatten an area of the cornea. However, for patients without a cornea, the available techniques for measuring IOP are insufficient to accurately determine their eye pressure. For instance, the Boston Keratoprosthesis (KPro) is a rigid artificial cornea implanted in patients who are unable to receive standard corneal transplantation. Standard IOP measurement techniques are unable to measure pressure due to the rigid back plate of the KPro device. As these patients are likely to develop glaucoma post-surgery, there is a need obtain direct measurements of IOP. The aim of the project is to design and optimize the existing KPro device and integrate the IOP sensor for frequent and direct measurement of eye pressure. Integrating the pressure sensor will enable patients to monitor their eye pressure and improve glaucoma management post corneal transplantation surgery.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments | Materials | Sensors

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