in-vivo investigation of an interferometric pressure measurement system for glaucoma management

Department: Mechanical & Aerospace Engineering
Faculty Advisor(s): Frank E. Talke

Primary Student
Name: Alex Minh Giang Phan
Phone: 310-701-0252
Grad Year: 2018

Evaluating an optical pressure measurement system for frequent and direct measurement of intraocular pressure (IOP) in vivo. The IOP measurement system consists of a miniaturized passive interferometric pressure sensor and a portable handheld optical reader. The sensor is 1.25 mm square and includes a deflecting silicon nitride membrane positioned 10 μm above a rigid glass substrate. The membrane deflects as a function of pressure. When monochromatic light is directed towards the sensor cavity, interference fringes are formed and can be analyzed to determine IOP. Two sensors were tested in vitro to characterize the behavior in a pressure range from 0 mmHg to 100 mmHg. The sensors then were integrated onto an intraocular lens and implanted during cataract surgery in two rabbits. A portable optical handheld reader consisting of an internal beam splitter, a monochromatic light source, and a digital single-lens reflex (DSLR) camera was also developed to optically capture interference patterns from the sensor in any setting

Industry Application Area(s)
Electronics/Photonics | Life Sciences/Medical Devices & Instruments | Materials

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