193. macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

Department: NanoEngineering
Faculty Advisor(s): Liangfang Zhang

Primary Student
Name: Pavimol Angsantikul
Email: pangsant@ucsd.edu
Phone: 858-263-5911
Grad Year: 2018

Abstract
Sepsis, resulting from uncontrolled inflammatory responses to bacterial infections, continues to cause high morbidity and mortality worldwide. Currently, effective sepsis treatments are lacking in the clinic, and care remains primarily supportive. Here we report the development of macrophage biomimetic nanoparticles for the management of sepsis. The nanoparticles, made by wrapping polymeric cores with cell membrane derived from macrophages, possess an antigenic exterior the same as the source cells. By acting as macrophage decoys, these nanoparticles bind and neutralize endotoxins that would otherwise trigger immune activation. In addition, these macrophage-like nanoparticles sequester proinflammatory cytokines and inhibit their ability to potentiate the sepsis cascade. In a mouse Escherichia coli bacteremia model, treatment with macrophage mimicking nanoparticles, termed MΦ-NPs, reduced proinflammatory cytokine levels, inhibited bacterial dissemination, and ultimately conferred a significant survival advantage to infected mice. Employing MΦ-NPs as a biomimetic detoxification strategy shows promise for improving patient outcomes, potentially shifting the current paradigm of sepsis management.

Industry Application Area(s)
Life Sciences/Medical Devices & Instruments

Related Links:

  1. http://www.pnas.org/content/114/43/11488.long

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