Faculty Presentations

2:30 p.m. - 4:30 p.m.
Price Center Forum (4th Floor)

Hear twenty-minute technical talks by Jacobs School of Engineering faculty.

2:30 p.m.
CHO Systems Biology Center
Nathan Lewis

Nathan Lewis, Professor, Department of Pediatrics, UC San Diego School of Medicine

"A systems approach to engineering mammalian cells for better therapeutics"

Over the past three decades, mammalian cells have emerged as key hosts for the production of therapeutic proteins. Indeed, of the top ten pharmaceuticals by global sales in 2014, six are produced in mammalian cells, such as Chinese hamster ovary (CHO) cells. Furthermore, in just the last few years, over half a trillion dollars worth of product has been in produced in CHO cells. However, despite the success of several protein-based drugs, there is a growing awareness of the importance of controlling critical quality attributes (CQAs) that impact drug safety and efficacy, and that rational cell line engineering is often needed to control product quality. The hurdles limiting mammalian cell engineering are just now being overcome with the emergence of novel tools, resources, and analysis methods. In the CHO systems biology center in the Jacobs School of Engineering at UCSD, we are now genomic and systems biology resources and big data analytics to guide the rational engineering mammalian cells. In this talk I will highlight the computational approaches to manage big data for cell engineering at to guide the development of better drugs and biosimilars.

3:00 p.m.
Bioengineering
Gabriel Silva

Gabriel Silva, Professor, Bioengineering, UC San Diego Jacobs School of Engineering

"Reverse engineering the brain: From neuroscience to engineering and back again"

The brain epitomizes a complex dynamical system, where the emergent properties that result from the interactions of the 'stuff' that makes it up, e.g. molecules, neurons, glia, and networks, far surpasses the properties of the individual components. From an engineering and design perspective, the question is how is this achieved? How do these components interact together as a dynamical system and what are the rules (algorithms) implemented in the biological substrate that achieve this? The answer to this has neurobiological and clinical implications because it would allow us to understand how the brain works in health and how it fails in disease, as well as what might be done to fix it. But it also has possible non-biological applications to engineered neuromimetic systems that attempt to reproduce the computational power and robustness of the biological brain. For example in areas such as robotics, data analytics, and novel neural computing architectures. This talk will discuss some of our own work past and present towards these goals as well as some recent work from others. And we will speculate on what might drive the field moving forward.

3:30 p.m.
Center for Microbiome Innovation
Pieter Dorrestein

Pieter Dorrestein, Professor, SPPS, Pharmacology, Chemistry and Biochemistry

"The Chemical Role Of 4 Pounds Of Bacteria That Live In And On Each Of Us"

Here we describe the generation, processing, and analysis of multi-omics data platforms from human, environmental, and animal samples as a part of the the newly established center for microbiome innovation and what opportunities there are to get involved with the center. With 16S rRNA amplicon, metagenomic and transcriptomic sequencing and mass spectrometry, we explored the relationship between chemistry and microbial communities. We will showcase how we can map such information with human skin and lungs in 3D. The first paper of the center that was submitted demonstrated that we can go from sample to data conclusions in less than 48 hours. While not yet routine, this achievement has far-reaching implications because it demonstrates that multi-omics methods can be applied in clinically relevant timeframes and approaches the speed of classical microbiology experiments.

4:00 p.m.
CaliBaja Center for Resilient Materials & Systems
Olivia Graeve

Olivia Graeve, Professor, Mechanical and Aerospace Engineering, UC San Diego Jacobs School of Engineering

"CALIBAJA CENTER FOR RESILIENT MATERIALS AND SYSTEMS: ADVANCED MATERIALS AND MANUFACTURING PROMOTING INTERDISCIPLINARY RESEARCH AND STUDENT MOBILITY"

The CaliBaja Center for Resilient Materials and Systems is to support and promote research activities and technology development in the CaliBaja region, with emphasis in three strong technology sectors of the region, aerospace, biomedical devices, and manufacturing, as well as to connect the humanities, environmental sciences, and social sciences to promote bi-national student mobility and scientific collaborations. The Center brings together a multidisciplinary team of researchers and scholars that are highly responsive to: (1) The challenge of designing materials and systems for extreme environments such as those found in a variety of engineering applications (i.e., ultra-high temperatures, extreme pressures and deformations, radiation, acidic conditions, etc.); (2) The challenge of exploring the extreme social and economic contrasts found along the Tijuana-San Diego border, the busiest border in the world, a place where social extremes collide and converge to form a unique social fabric and an emerging bi-national identity. Both challenges require human capital highly versed in the newest technologies and with a cultural understanding that can promote effective links between the two sides of the border. Thus, our Center is built around the concept of designing new materials and systems for extreme environments, as well as educating a technology-focused workforce for a thriving 21st century bi-national region. In the area of technology development, improvement and continued innovation of advanced technologies for aerospace, energy, nuclear, biomedical, and national security applications, is critically dependent on the design and performance enhancement of new materials and devices. In particular, unique materials are required that can withstand extremes in stress, strain, temperature, pressure, chemical reactivity, photon or radiation flux, and electric or magnetic fields.


Contact:   researchexpo@soe.ucsd.edu   (858) 534-6068