Faculty-Emeritus, Institute for Engineering Medicine
Research on how the forces of blood flow impact the cardiovascular system. His studies are leading to new understanding about the pathophysiological mechanisms of atherosclerosis and hypertension, and to the development of therapeutical approaches for cardiovascular disease.
Professor Chien's research on how blood flow regulates interaction between the blood stream, blood cells and artery walls also leads to new information relevant to other types of cells, e.g., stem cells and cancer cells. At the molecular level, he is discovering how mechanical forces signal gene expression to cause cell growth, migration and cell death. Chien takes a multidisciplinary, integrative approach that combines engineering and biomedical sciences. He employs an array of technologies including nanotechnology, DNA microarrary, bioinformatics, cell biophysics and biomechanics in his research on the cardiovascular system.
Shu Chien joined UCSD in 1988 and became the founding chair of the Department of Bioengineering in 1994. In 2008, Chien became the founding Director of UC San Diego's new Institute of Engineering in Medicine to foster collaborations among the faculty of UCSD and with research institutes and biomedical companies in San Diego. As principal investigator on the Whitaker Foundation Development Award (1993) and Leadership Award (1998), Chien played a major role in establishing UCSD' bioengineering program as one of the top programs in the country. As founding Director of the UC Systemwide Bioengineering Institute in California, he has contributed to collaborations in research and education among the ten UC campuses. In September 2006, Chien was named the inaugural holder of the Y.C. Fung Endowed Chair in Bioengineering at the Jacobs School. He is a member of the National Academy of Engineering, Institute of Medicine, National Academy of Sciences, and American Academy of Arts and Sciences. Chien won the US National Medal of Science in 2011. He received his M.D. from the National Taiwan University and his Ph.D. in Physiology from Columbia University, where he was a professor from 1969 to 1988.